Twyford is on the main railway line from London Paddington and is one stop away from the major rail interchange at Reading. Rail passengers travelling to Henley-on-Thames will usually change trains at Twyford.
Trains on the main-line stop three or four times and hour. The service to Henley is hourly for most of the day.
There is an hourly bus service from Reading to Twyford that continues on via a rather circular route to Wokingham.
Car drivers will usually approach Twyford by coming off the M4 at Maidenhead and taking the A4 west for about five miles. Turn left when you see the sign to Twyford and before long you will find yourself at Twyford crossroads. Parking can be found in the Waitrose supermarket car park, or in the small car park in Polehampton Close described below.